Clinical investigation of intra-articular injection in treatment of rheumatoid arthritis

Objective: To investigate the clinical significance of intra-articular injecting Methotrexate and Compound Betamethasone in treating rheumatoid arthritis.Methods: 98 patients with rheumatoid arthritis definitely diagnosed in our hospital from October 2007 to October 2010 were selected.They were divided into treatment group and control group randomly,each 49 cases.The treatment group was treated with Methotrexate 10 mg/w,and Compound Betamethasone 7 mg/d,while the control group was treated with Methotrexate 10 mg/w,and low dose(≤10 mg/d) Prednisone.Their quantity of swelling joint and joint with tenderness,CRP,ESR,RF were observed,and total efficiency of the two groups were compared.Results: The reducing quantity of swelling joint and joint with tenderness,CRP,ESR,RF and the total efficiency of treatment group were significantly higher than those of the control group(P0.05 or P0.01).The incidence of adverse reactions of the treatment group(4.1%) was significantly lower than that of the control group(12.2%)(P0.05).Conclusion:Intra-articular injecting Methotrexate and Compound Betamethasone shows obvious advantages in efficacy,safety,adverse reaction and tolerance.Thus it can be recognized as a prior choice in treating rheumatoid arthritis.