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2004•Chinese Journal of Otorhinolaryngology-skull Base SurgeryRequires access

Clinical pathological significance of the expression of epidermal growth factor receptor in nasopharyngeal carcinoma

Fu Jiang

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Abstract

Objective To explore the relationship between epidermal growth factor receptor (EGFR) and cell proliferation and transformation. Methods In this study, EGFR expression was examined in 24 Specimens of human nomal nasopharynx mucosa and 60 Specimens of nasopharyngeal Carcinoma. Results EGFR expression in nasopharyngeal Carcinoma was heterogareous. The EGFR Positive ration (55%) was higher than that of normal nasopharynx mucosa (0%) (P 0.05 ), statistically significant correlation was observed between EGFR and positive expression and the presence of regional lymph node metastasis and the patients had poor prognosis. Conclussion The EGFR expression in nasopharyngeal Carcinoma was a significant predicting factor for proliferative status of the Carcinomal Cell, presence or not presence of regional lymph node metastasis and prognosis of the patients.

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What this paper is about

Objective To explore the relationship between epidermal growth factor receptor (EGFR) and cell proliferation and transformation. Methods In this study, EGFR expression was examined in 24 Specimens of human nomal nasopharynx mucosa and 60 Specimens of nasopharyngeal Carcinoma. Results EGFR expression in nasopharyngeal Carcinoma was heterogareous. The EGFR Positive ration (55%) was higher than that of normal nasopharynx mucosa (0%) (P 0.05 ), statistically significant correlation was observed between EGFR and positive expression and the presence of regional lymph node metastasis and the patients had poor prognosis. Conclussion The EGFR expression in nasopharyngeal Carcinoma was a significant predicting factor for proliferative status of the Carcinomal Cell, presence or not presence of regional lymph node metastasis and prognosis of the patients.

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Available abstract

Objective To explore the relationship between epidermal growth factor receptor (EGFR) and cell proliferation and transformation. Methods In this study, EGFR expression was examined in 24 Specimens of human nomal nasopharynx mucosa and 60 Specimens of nasopharyngeal Carcinoma. Results EGFR expression in nasopharyngeal Carcinoma was heterogareous. The EGFR Positive ration (55%) was higher than that of normal nasopharynx mucosa (0%) (P 0.05 ), statistically significant correlation was observed between EGFR and positive expression and the presence of regional lymph node metastasis and the patients had poor prognosis. Conclussion The EGFR expression in nasopharyngeal Carcinoma was a significant predicting factor for proliferative status of the Carcinomal Cell, presence or not presence of regional lymph node metastasis and prognosis of the patients.

Key concepts: Nasopharyngeal carcinoma, Epidermal growth factor receptor, Pathological, Medicine, Lymph node metastasis, Carcinoma, Pathology, Epidermal growth factor

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