2002•The Practical Journal of CancerRequires access
Clinical Significance of Fas、FasL and PCNA Expression in Gastric Cancer Tissue
Zhan He
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Abstract
Objective To study the expression of Fas?FasL and PCNA in gastric cancer tissue and its clinical significance.Methods 50 gastric cancer specimens and 10 normal gastric mucosa tissues were collected and continuous paraffin slices were made from the normal gastric mucosa,tissues of 5 cm distance from gastric cancer tissue,paracarcinoma tissue and gastric cancer tissue.The expressions of Fas?FasL and PCNA in the above mentioned tissuse were studied with immunohistochemistry S P method.Results The expressions of Fas and FasL were not associated with tumor grade,stage and metastases in lymph nodes.In gastric cancer,the expression of PCNA was correlated with the degree of differentiation,stage and metastases in lymph nodes.Conclusion The expression of Fas and FasL is involved in gastric tumorigenesis,but may not be related with gastric cancer progression.Fas/FasL system may play an important role in immune privilege of the development and progression of gastric cancer.PCNA is an important marker to reflect gastric cancer cell proliferation.