Effect of aminoguanidine on dynamic changes of plasma nitric oxide and endothelin on traumatic shock in rats.

Objective To evaluate the effect of aminoguanidine(AG),one kind of nitric oxide synthese(NOS)antagonist,on the plasma concentration of nitric oxide(NO),endothelin(ET)and oxygen partial pressure in tissues during the pathogenesis of traumatic shock in rats.Methods Rat model of traumatic shock was established in Sprague-Daulay rats,which were randomly divided into two groups:control group and treatment group.The plasma concentration of NO,ET and oxygen partial pressure in the tissues from the skeletal muscles,liver and small intestine were measured before and after shock and 1,3,5,and 12h after resuscitation.Meanwhile,the hemodynamics of the rat and their survival rates at 12 and 24h were recorded.Results The changes of plasma NO,ET levels and oxygen partial pressure in tissues of both groups were statistically significant after traumatic shock(P0.05).Plasma NO and ET concentration in the late stage of traumatic shock were significantly lower in the treatment group than in the control group(P0.05),while oxygen partial pressure in the liver and small intestine in the late stage of shock were significantly higher in the treatment group(P0.05).The blood pressure after resuscitation and the survival rates at 12 and 24h were also significantly different between the two groups(P0.05).Conclusion AG can decrease plasma NO and ET levels,improve blood pressure and oxygen partial pressure of internal organs which can significantly improve the prognosis of rats with traumatic shock.