Protective effect of L-arginine on a rat model of traumatic shock

Objective To investigate the protective effect of L-arginine on rat model of hemorrhagic shock.Methods Rat models of traumatic shock were established by making the posterior limb of the rats.L-arginine (L-Arg,the precursor of NO synthesis 10,100,300 mg/kg),Nω-nitro-L-arginine-methyl ester(L-NAME,non-selective NOS inhibitor 10 mg/kg)and aminoguanidine (AG,selective iNOS inhibitor 10 mg/kg)were injected intravenously when resuscitation,survival time and survival rate were observed.Results The survival time of L-Arg group and AG group prolonged apparently,and survival rate was also increased.Conclusion L-Arg has beneficial effects on traumatic shock rats.