Relationship of serum 8-OHdG and VEGF with diabetic nephropathy in diabetics

Objective To investigate the relationship of serum 8-hydroxy-guanine(8-OHdG) and vascular endothelial growth factor(VEGF) with diabetic nephropathy(DN).Methods The levels of serum 8-OHdG,VEGF,and 24 h albuminuria were measured by ELISA in 71 DN patients,73 T2DM patients,and 47 healthy people.The results were compared to observe the difference among them.Results The levels of serum 8-OhdG and VEGF in the diabetic nephropathy patients were significantly higher than in the T2DM patients(P0.01).The levels of serum 8-OhdG and VEGF in the T2DM patients were higher than in the normal control group(P0.05).The levels of serum 8-OhdG and VEGF in the macroalbuminuria group were significantly higher than in the microalbuminuria group(P0.05).The levels of serum 8-OhdG and VEGF in the HbA1c10% group were significantly higher than in the HbA1c9% group(P0.05).Conclusion The diabetic nephropathy is related with serum 8-OHdG and VEGF.Oxidative stress and VEGF play important roles in the pathogenesis of diabetic nephropathy.