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Experimental Study of CCl_4 and HSA Induced Animal Models of Liver Fibrosis

Pei Li

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Abstract

In order to investigate the availability of animal models of liver fibrosis,carbon tetrachloride(CCl 4)and human serum albumin(HSA) induced rats liver fibrosis were developed and survival rates,serum concentration of ALT,AST,LDH,hepatic collagen contents and pathological examination were served as observing parameters.Results showed that these indicators in two models group were significantly different from those of normal group.They could reflect the formation of liver fibrosis and could be selected as observing parameters for treatments of experimental liver fibrosis.

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What this paper is about

In order to investigate the availability of animal models of liver fibrosis,carbon tetrachloride(CCl 4)and human serum albumin(HSA) induced rats liver fibrosis were developed and survival rates,serum concentration of ALT,AST,LDH,hepatic collagen contents and pathological examination were served as observing parameters.Results showed that these indicators in two models group were significantly different from those of normal group.They could reflect the formation of liver fibrosis and could be selected as observing parameters for treatments of experimental liver fibrosis.

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Available abstract

In order to investigate the availability of animal models of liver fibrosis,carbon tetrachloride(CCl 4)and human serum albumin(HSA) induced rats liver fibrosis were developed and survival rates,serum concentration of ALT,AST,LDH,hepatic collagen contents and pathological examination were served as observing parameters.Results showed that these indicators in two models group were significantly different from those of normal group.They could reflect the formation of liver fibrosis and could be selected as observing parameters for treatments of experimental liver fibrosis.

Key concepts: Carbon tetrachloride, Liver fibrosis, Fibrosis, Pathological, CCL4, Animal model, Albumin, Internal medicine

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