Effect of Short-term Continuous Subcutaneous Insulin Infusion Treatment on Beta-cell Function and Insulin Resistance in Type 2 Diabetic Patient

Objective To observe the effect of short-term continuous subcutaneous insulin infusion(CSII) on blood glucose,beta-cell function and insulin resistance in patients with newly-diagnosed type 2 diabetes mellitus.Methods Seventy-two patients with newly-diagnosed type 2 diabetes mellitus receiving two weeks of CSII therapy were analyzed.The levels of the fasting plasma glucose(FPG),2 hours postpradial glucose(2hPG),and glycosylated hemoglobin A1c(HbA1c),fast insulin(FINS),2 hours postpradial insulin and insulin secretion indexes(HOMA-β) and insulin resistance index(HOMA-IR) were determined and compared before and after CSII.Results The level of blood glucose was well stably controlled by CSII.The levels of FINS,HOMA-B were increased significantly two weeks after intensive treatment with CSII.The HOMA-IR were decreased significantly.Conclusion Short-term CSII intensive treatment can stably control the level of blood sugar,improve the function of beta-cell and reduce the resistance to insulin in type 2 diabetic patients.