2007•Tianjin Yike Daxue xuebaoRequires access
Evaluation of E-cadherin in the prediction of liver metastasis of colorectal carcinoma
Han Liang
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Abstract
Objective: To investigate the abnormal expression of E-cadherin in colorectal carcinoma and its correlation with liver metastasis of colorectal carcinoma. Methods: The abnormal expression of E-cadherin was detected using immunohistochemical methods in 30 colorectal carcinoma tissues without liver metastasis,30 with synchronal liver metastasis,30 with heterochronia liver metastasis and 30 surrounding normal colorectal tissues. Results:(1)The abnormal expression of E-cadherin in colorectal carcinoma was significantly higher than that in surrounding normal colorectal tissue (P0.05); The abnormal expression of E-cadherin in colorectal carcinoma was related to depth of invasion,lymph node metastasis and Dukes stages(P0.05). (2) The abnormal expression of E-cadherin in colorectal carcinoma with synchronal or heterochronia liver metastasis was significantly higher than that in tissues without liver metastasis(P0.05). Conclusion: E-cadherin may play a role in the process of developing hepatic metastasis. The abnormal expression of E-cadherin in colorectal carcinoma may be considered as a new clinical indicator for monitor of hepatic metastasis and prognosis of colorectal carcinoma.