The Expression and the Significance of E-cadherin and γ-catenin in Colorectal Carcinoma

Objective To determine the expression of E-cadherin/γ-catenin complex in colorectal carcinoma and investigate the relationship between E-cadherin/γ-catenin complex and the clinicopathologic features.Methods 60 cases of tissues were examined,and the clinical pathologic parameters was detected.Immunohistochemical dicho-step method was used to detect the E-cadherin/γ-catenin and to analyze their significance and the correlation between them.Results The expression rates of E-cadherin:normal colorectal tissues colorectal adenoma tissues colorectal carcinoma tissues.The expression rates of γ-catenin:normal colorectal tissues colorectal adenoma tissues and normal colorectal tissues colorectal carcinoma tissues.The expression level of E-cadherin was closely related with Dukes stage,metastasis(includ-ing lymphatic metastasis and distant place metastasis),depth of infiltration and differentiation.The expression level of γ-catenin was closely related with lymphatic metastasis and distant metastasis.The expression of the E-cadherin and γ-catenin both decreased in colorectal carcino-ma tissues,but the analysis of their correlation showed there was no statistic significance.Conclusion The expression level of E-cadherin is related to Dukes stage,metastasis(including lymphatic metastasis and distant metastasis),depth of infiltration,differentiation.And the expres-sion of γ-catenin is related to lymphatic metastasis and distant metastasis.Detecting their expression might be useful prognostic indicators and give a theoretical help in the therapy of colorectal carcinoma.