The Rat Chronic Toxicity Test of Sishun Qingliangyin

ObjectiveTo observe the effects of Sishun Qingliangyin on the rat chronic toxicity test.MethodsThe rats were orally given for 3 weeks with the doses of 40,28 and 19.6 g/kg(being 44.8,31.4 and 22 times of clinic dose) and for 6 days of stopping administration,the rat weights,organ coefficients,the indexes of hematology and biochemistry were determined,and the pathological examination were carried out.ResultsThe outer appearance and behavior,weights, organ coefficients,the indexes of hematology and biochemistry in rats has no significant difference by comparing with control group;the pathological examination was not discovered significant pathological changes with relation of drug toxicity and the delayed toxicity reaction in stopping administration later.ConclusionThe Sishun Qingliangyin has no significant toxicity for long-term administration in rats,and infers that the drawing up doses in clinic will be safe.