clinical observation of patients with severe hepatitis treated by artificial levers support systerm

Objective To investigate the curative effect of artificial livers support system(ALSS) in patients with hepatitis severe and methods of decreasing the adverse reactions.Methods 48 patients were arranged in the observed group and 32 patients in the normal control.On the basis of the comprehensive protective treatment for liver on both two groups,meanwhile,ALSS was used in the observed group.Observe the rate of improvement and curativeness,the total rate of effectiveness,the average period of hospitalization and the main labratory monitorings as well as the adverse reactions of the treatment of ALSS in different periods of severe.Results The improvement rate of the early,middle,terminal period patients in the observed group is 100.00% ,80.00% ,28.57% respectively,the total effectiveness rate is 72.92% .Comparing with the former,the result of the normal control is 66.67% ,54.55% ,10.00% respectively,the total effectiveness rate is 46.87% .The average period of hospitalization of clinical cure cases'.observed group (21.25+ 12.69)d,normal control (52.36+ 17.27)d,there is a significant difference between the two groups (P0.001) .20 patients among 232 patients who were treated by ALSS suffered from adverse reaction,and the rate is 8.62% .Conclusions ALSS can provide patients with comparatively secure and effective treatment for patients with severe,especially.for the early and middle period one.Adverse reaction can be decreased by reducing the dosage of heparin,being more rigorous escptic manipulation and taking preventive medication.