Combined use of ozone and collagenase injection for the treatment of lumbar disc herniation:comparison of therapeutic efficacy with simple ozone injection

Objective To observe the therapeutic effects of combined use of ozone and collagenase injection in treating lumbar disc herniation and to make a comparison of therapeutic efficacy with simple ozone injection.Methods Under DSA guidance,percutaneous puncturing of diseased lumbar disk with a gauge 9 needle was performed in 76 patient with lumbar disc herniation.After the needle position was confirmed in the right site simple ozone injection(control group,n=38) or combined use of ozone and collagenase injection(study group,n=38) was carried outs.The clinical results were evaluated and compared between two groups.Results After the treatment,all 76 patients were followed up regularly at 1,3 and 6 months.At 1,3 and 6 months after the therapy,the effective rate of study group was 89.5%,92.1% and 94.7% respectively,while the effective rate of control group was 86.8%,84.2% and 81.6% respectively.Conclusion For the treatment of lumbar disc herniation,the therapeutic effect of combined use of ozone and collagenase injection is much better than that by using simple ozone injection,moreover,it carries a quite stable long-term efficacy.