Effects of Leukocyte Depleted Blood Transfusion on Immune Function

Objective:To study the effects of leukocyte depleted blood transfusion on immune function.Method:162 patients blood transfusion were randomly divided into two groups,the observation group(n=81 cases) and the control group(n=81 cases).The control group was treated through the conventional blood transfusion,while the observation group was treated through leukocyte depleted blood transfusion.T cells subsets and immune globulin protein were measured before and after blood transfusion.Result:No significant difference about mean body temperature was observed between the two groups before and after blood transfusion(P0.05).Before and after transfusion temperature mean difference, the observation group was significantly lower than that of the control group(P0.05).Transfusion reaction rate in the observation group was significantly lower than the control group(P0.01).Serum CD4+,CD4+/CD8+were significantly lowered in the control(P0.05).The observation group before and after treatment, serum CD4+,CD4+/CD8+ had no significant change(P0.05).After treatment,serum CD4+,CD4+/CD8+ in the control group was lower than the observation group(P0.05).Serum Ig G,Ig A,Ig M,Ig E of the control group were significantly lowered(P0.05).Serum Ig G,Ig A,Ig M,Ig E of the observation group had no significant change(P0.05).The two groups after treatment group,serum Ig G,Ig A,Ig M,Ig E decreased more significantly in the control(P0.05).Conclusion:Leukoreduced blood transfusion had smaller effects on immune function in patients.