Infleuce of perioperative blood transfusion on cell immune function in patients with primary brain tumors

Objective Measuring the cell immune function after pre-operative transfusion,to provide scientific evidence for the cerebroma patients who received transfusion.Methods Sixty-four cerebroma patients about to operative randomly divided into transfusion group(46 cases),non-transfusion group(15 cases) and 40 healthy volunteers as control group.Vessel blood samples drawn pre-operation,3 and 14 and 30 days after operation for measurement.Flow cytometer was used to measure the CD3~+T cells,CD4~+T cells,CD8~+T cells,CD4~+/CD8~+T cells ratio and NK cells.Results There was no evident different between the transfusion group and control group before transfusion.Three days after operation,there was remarkable different(P0.05).On 14 and 30 days after operation,there was no evident different to 3 days after operation.But lower than the level of pre-operation(P0.05).There was no evident difference between the non-transfusion group and control group before transfusion and it had difference 3 days after operation.Change of CD8~+ cells was not remarkable.It returned to the level of pre-operation14 days after operation.Difference between groups:there was no evident difference before operation and transfusion.3 days after operation,CD3~+T cells,CD4~+T cells,CD8~+T cells,and CD4~+/CD8~+T cells ratio in the non-transfusion group were no evident difference to the transfusion group.14 and 30 days,the levels in the non-transfusion group were remarkably higher than that of the transfusion group(P0.05).Conclusion Blood transfusion can depress the cellular immune function of cerebroma patients and it should be cautious to these patients in clinical practice.