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Determination of ginsenoside Rg_1,Re,Rb_1 in Chanshu granule by HPLC

LI Shu-cui

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Abstract

OBJECTIVE To establish an HPLC method for the determination of ginsenoside Rb1,Re,Rg1 in Chanshu granule.METHODS The analytical method was carried out with a Diamosil C18(250 mm×4.6 mm,5μm) at 25 ℃,and the mobile phase consisted of acetonitrile and water for gradient elution with the flow rate at 1.0 mL·min-1.The detection wavelength was 203 nm.RESULTS The linear ranges for ginsenoside Rbl,Re,Rg1 were 0.424-4.24 mg,0.4312-4.312 mg and 0.41-4.12 mg,respectively.The average recoveries and RSD all met requirements.CONCLUSION The quantitative method for the determination is feasible and beneficial to control the quality of Chanshu granule.

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What this paper is about

OBJECTIVE To establish an HPLC method for the determination of ginsenoside Rb1,Re,Rg1 in Chanshu granule.METHODS The analytical method was carried out with a Diamosil C18(250 mm×4.6 mm,5μm) at 25 ℃,and the mobile phase consisted of acetonitrile and water for gradient elution with the flow rate at 1.0 mL·min-1.The detection wavelength was 203 nm.RESULTS The linear ranges for ginsenoside Rbl,Re,Rg1 were 0.424-4.24 mg,0.4312-4.312 mg and 0.41-4.12 mg,respectively.The average recoveries and RSD all met requirements.CONCLUSION The quantitative method for the determination is feasible and beneficial to control the quality of Chanshu granule.

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Available abstract

OBJECTIVE To establish an HPLC method for the determination of ginsenoside Rb1,Re,Rg1 in Chanshu granule.METHODS The analytical method was carried out with a Diamosil C18(250 mm×4.6 mm,5μm) at 25 ℃,and the mobile phase consisted of acetonitrile and water for gradient elution with the flow rate at 1.0 mL·min-1.The detection wavelength was 203 nm.RESULTS The linear ranges for ginsenoside Rbl,Re,Rg1 were 0.424-4.24 mg,0.4312-4.312 mg and 0.41-4.12 mg,respectively.The average recoveries and RSD all met requirements.CONCLUSION The quantitative method for the determination is feasible and beneficial to control the quality of Chanshu granule.

Key concepts: Chemistry, Ginsenoside Rg1, Granule (geology), Chromatography, Ginsenoside, High-performance liquid chromatography, Gradient elution, Acetonitrile

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Determination of ginsenoside Rg_1,Re,Rb_1 in Chanshu granule by HPLC — Research Paper | ScholarLens