Monitoring of drug resistance of coagulase-negative staphylococcus isolates in 2008-2011

Objective To understand the infecting status and the drug resistance of coagulase-negative staphylococcus(CNS) isolated from the Second Affiliated Hospital of Guangzhou Medical College during 2008-2011.Methods Referring to National Guide to Clinical Laboratory Procedures,CNS was cultured and indentified.The drug susceptibility testing was performed by K-B method.The results were assessed according to the latest version of NCCLS breakpoints.Results A total of 913 CNS strains were isolated(accounted for 27.51%).There were 647 MRCNS strains(accounted for 70.86% of CNS).The drug-resistance rates of CNS isolates to penicillin was the highest(99.1%),followed by clindamycin,trimethoprim and sulphame-thoxazole,gentamicin and generation quinolones etc.The drug-resistance rates to rifampin,fusidate sodium and norvancomycin were the lowest.Conclusion The resistance rates of CNS to most antibacterial agents are incessantly increased and monitoring of drug resistance be conducted to guide the clinical reasonable use of antibiotics,delay the occurrence of drug resistance and control the spread of resistant strains.