Chordoid glioma of the third ventricle:a case report and review of literature

Objective To study the clinicopathological features,immunophenotypes and differential diagnosis of chordoid glioma of the third ventricle(CGTV),so as to provide more information for clinical doctors.Methods The clinical data,morphology,immunohistochemical labeling and differential diagnosis of a CGTV patient were discussed,and the literatures were reviewed.Results The patients was a 53 years old female,with the main symptoms including visual decrease,deficit of visual field of the nasal side,and headache.CT and MRI showed that the tumor was located at the suprasella turcica.Microscopically,the tumor was composed of epithelioid cells in a mucinous background with abundant esinophilic cytoplasm in the nests and strands.There was a mixed chronic inflammatory infiltrate of lymphocytes and plasma cells around the tumor.Necrosis and endothelial proliferation were not identified.Tumor cells were positively stained for glial fibrillary acidic protein(GFAP)and vimentin;there were also focus staining of epithelial membrane antigen(EMA).Less than 1% of the cells were positive of Ki-67.Conclusions CGTV is a rare tumor of the central nervous system;it can be differentiated from other tumors by the clinical and histopathological features and immunohistochemical staining results.