Clinical and pathological features of chordoid meningioma

Objective To study the clinical and pathological features of chordoid meningioma.Methods One case of chordoid meningioma was investigated.In this case histopathology,histochemistry and immunohistochemistry were studied.The clinical and pathological features were explored and related literatures were reviewed.Results Chordoid meningioma may or may not associate with Castleman syndrome.Lobular-and strip-shaped tumor cells were seen in the mucoid matrix.The cytoplasm was hypochromic or oxychromatic.There were some droplets cells in the mucoid matrix which were similar to chordoma-like cells.Typical meningiomatous pattern was observed focally.The histochemical examination showed periodic acid schiff(PAS) staining positive.Immunohistochemical examination showed positive for epithelial membrane antigen(EMA),vimentin and epidermal growth factor receptor(EGFR),focal positive for cytokeratin(CK) and S-100 protein,negative for carcinoembryonic antigen(CEA).Ki-67 antigen labeling index was low( 1%).p53 protein expression positive was seen in 35% tumor cells.Conclusion Chordoid meningioma is a rare variant of meningioma.The confirmed diagnosis can be made by clinical data,and histopathological,histochemical and immunohistochemical examination.The prognosis needs to be studied further.