RISK FACTORS OF HBV INTRAUTERINE INFECTION

[Objective] To explore the hepatitis B virus(HBV) carrying rate among pregnant women and HBV intrauterine infection rate in neonates of pregnant women with HBV,and to analyze the risk factors of HBV intrauterine infection. [Methods] pregnant women with HBV were screened as the target population. After delivery,umbilical bloods of neonates were tested. Neonates with HBV by intrauterine infection were selected as cases,while the rest as controls,so as to analyze the risk factors of intrauterine infection. [Results] A total of 3415 pregnant women were tested in Hefei city from 2002 to 2004,and HBV carrying rate was 3.34%(114 /3415) . The carrying rate of HBV in urban pregnant women(2.91%) was significantly lower than rural pregnant wome(5.62%)(χ2 = 9.23,P﹤0.01) . 33 of 112 neonates were infected with HBV(29.46%) . Multivariate unconditional logistics regression analysis indicated that the positive of HBeAg(OR=3.14,95%CI:1.23-8.04) ,history of vagina bleeding(OR=4.47,95%CI:1.18-16.99) were correlated with HBV intrauterine infection. [Conclusion] HBV carrying rate showed to be low among the pregnant women in Hefei. The HBV carrying rate of urban pregnant women was significantly lower than rural pregnant women. Positive maternal HBeAg and history of vagina bleeding may be the risk factors of HBV intrauterine infection.