Distribution and drug resistance analysis of pathogens in a hospital from January 2012 to October 2012

Objective To explore bacteria distribution and drug resistance in a hospital,to analyze rationality of physicians,prescription according to antibiotic to antibiotic susceptibility of antibiotics,so as to guide clinical rational choice.Methods Using retrospective method we analyzed samples of bacteria strain sent by respective clinical departments from January 2012 to October 2012,and observed the infectious patients after treating with antibiotics based on results of drug sensitivity test.Results A total of 805 strains of pathogenic bacteria were isolated,of which 114 strains of Gram-positive bacteria(14.2%),553 strains of gram-negative bacteria(68.7%),138 other strains of pathogenic bacteria(17.1%).After isolation of Gram-positive bacteria there was a high rate of drug resistance of Staphylococcus aureus and Staphylococcus epidermidis.As for gram-negative bacteria Escherichia coli bacteria,Acinetobacter baumannii Acinetobacter resistance rate were higher.Gram-negative bacilli had high rates of drug resistance to penicillins,cephalosporins.Enzyme-containing antimicrobial agents of cefoperazone and sulbactam,piperacillin and tazobactam were sensitive to gram-negative bacilli with an average rate of 82.3%.Imipenem and cilastain sodium was sensitive to Klebsiella pneumoniae,Pseudomonas aeruginosa bacteria,and Escherichia coli.653 cases of patients got better accounting for,81.1%.Conclusion As for the possible ESBLs-producing or multi-drug resistance of gram negative bacilli infection we should choose cefoperazone and sulbactam,piperacillin and tazobactam,and imipenem which have higher sensitivity.Most of the doctors in our hospital prescribe in accordance with the results of drug sersitivity test,which can be an important reperence for clinical treatment.