Clinical study of immature follicle puncture technique in treatment of infertile women with polycystic ovary syndrome

Objective: To evaluate the effect of immature follicle puncture technique on the polycystic ovary(syndrome)(PCOS)associated infertility.Methods:Eleven infertile women with clomiphene-resistant PCOS were included in the study.All women underwent the ultrasound-guided immature follicle puncture after menstruation.Serum hormone levels,menstrual period and the basic follicle number were monitored after the operation.Results: One woman became pregnant after the follicle puncture by means of in vitro maturation and embryo-transfer.2 of the 10 women(20%) had spontaneous ovulation and were pregnant 8 weeks after operation,others had improved menstrual period.Elevated serum levels of luteinizing hormone and testosterone decreased slightly but not significantly after the operation.The basic follicle number decreased(significantly) after the operation.Conclusions:Immature follicle puncture treatment can improve the endocrine condition,shorten(menstrual) period,decrease the basic follicle number,and achieve pregnancy in clomiphene-resistant PCOS(patients.) This technique is simple,economic and might be a new ideal approach if combined with in vitro(maturation) to the treatment of women with various causes of infertility.