Effects of spina date seed extract,schisandra chinens P.E compound on the hypnotic of mice

Objective To study the effects of spina date seed extract,schisandra chinens P.E compound on the hypnotic of mice.Methods 50 ICR mice were randomly divided into normal control group,spina date seed extract,schisandra chinens P.E compound(0.075 g/kg,0.15 g/kg,0.3 g/kg) group and zaoren sedative capsule(0.45 g/kg)group.After giving drugs via oral gavage for seven days,the effects of the hypnotic of mice was studied by the experiments of sleep-induced directly,prolonging sleeping time induced by pentobarbital sodium,affecting mice sleeping rate under the threshold hypnogenesis dosage of pentobarbital sodium and affecting sleeping delitescence induced by tobarbital sodium.Results Spina date seed extract,schisandra chinens P.E compound had not sleep-induced directly whereas the compounds could significance prolong sleeping time induced by pentobarbital sodium(P0.05,P0.01),increased the incidence rate of sleeping induced by subthreshold dose pentobarbital sodium(P0.05,P0.01) and shorten sleeping delitescence induced by tobarbital sodium(P0.05,P0.01).Conclusion Spina date seed extract,schisandra chinens P.E compound have obvious sedative and hypnotic effects and can improve sleeping efficiently.