The significance of c-reactive protein and interleukin-1β and tumor necrosis factor-alpha in elderly patient with chronic obstructive pulmonary disease

Objective To explore the clinical significance of C-reactive protein(CRP),interleukin-1β(IL-1β)and tumor necrosis factor-alpha(TNF-α) in the blood serum of the elderly patients with chronic obstructive pulmonary disease(COPD).Methods To detect the expression of CRP,IL-1β and TNF-αin the blood serum of the elderly patients with chronic obstructive pulmonary disease(COPD)and explore the clinical significance of CRP,IL-1β and TNF-α in AEC0PD.Results The concentration of CRP,IL-1βand TNF-α in the control group were significantly lower than those in the COPD group(P0.01),either during exacerbation or remission.The levels of cytokines were lower in patient with COPD during exacerbation than those during remission.Conclusion The expression level of CRP,IL-1β and TNF-α in the serum of elderly patients with COPD increased evidently at its acute exacerbation phrase,which suggests that CRP,IL-1β and TNF-α may be involved in the pathogenesis of AECOPD.The cytokines CRP,IL-1β and TNF-αplayed important role in the development and exacerbation of COPD and were closely related to systemic inflammatory reaction.