Expression and Clinical Significance of PI3K,PTEN and AKT Protein in Renal Clear Cell Carcinoma

Objective To detect PI3K,PTEN and Akt protein expression in renal clear cell carcinoma tissues and to analyze the correlation between expression and and its clinical pathological features.Methods The expression of PI3K protein,AKT protein and PTEN protein in renal clear cell carcinoma and normal renal tissues were detected by immunohistochemical method.Results ①The positive expression rate of PI3K and AKT protein in renal clear cell carcinoma was 81.67%(49/60) and 78.33%(47/60) respectively and they were significantly higher than those in the tissues adjacent to carcinoma(10% and 15%,P0.05).PTEN protein positive expression rate in renal clear cell carcinoma tissue was 38.33%(23/60) and it was significantly lower than that in the tissues adjacent to carcinoma(88.33%,P0.05).②The protein expression of PI3K,AKT and PTEN did showed significant difference in different age and size of tumor(P0.05) while significant difference of expression of PI3K,AKT and PTEN was found in different pathological grades and clinical stages(P0.05).③PTEN,PI3K and Akt protein expression showed significantly negative correlation(r=-0.338 and r=-0.325) while PI3K and Akt protein expression was significantly positive correlation(r=0.391).Conclusion PI3K and Akt protein show high expression in renal clear cell carcinoma tissues.PTEN shows loss high proportion in renal clear cell carcinoma tissues and it plays an important role in occurrence and development of renal clear cell carcinoma.