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The Relationship Between PTEN Expression and PI3K/AKT Signal Pathway in Colon Carcinoma

FU Dai-gan

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Abstract

Objective To investigate the expression of PTEN in carcinogenesis and development of colon carcinoma and to reveal their correlation with the PI3K/AKT pathway. Methods The expressions of PTEN and p-AKT were detected by immunohistochemistry and western blotting in 32 specimens from patients with colon carcinoma. Results The positive rate of p-PTEN was significantly lower in colon carcinoma (31.25%) than that in normal control tissues (96.87%,P0.01),and the positive rate of p-AKT was significantly higher in colon carcinoma (87.5%) than that in normal control tissues (15.62%,P0.01),and expression level of PTEN and p-AKT were related to histological differentiation,distant invasion,lymph node metastasis and Duke's stage (P0.05). A negative correlation was observed between the expression of PTEN and p-AKT proteins. (r=-0.872,P0.01). Conclusion The over-expression of AKT accompanied by the loss of PTEN involves carcinogenesis and development of colon carcinoma.

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What this paper is about

Objective To investigate the expression of PTEN in carcinogenesis and development of colon carcinoma and to reveal their correlation with the PI3K/AKT pathway. Methods The expressions of PTEN and p-AKT were detected by immunohistochemistry and western blotting in 32 specimens from patients with colon carcinoma. Results The positive rate of p-PTEN was significantly lower in colon carcinoma (31.25%) than that in normal control tissues (96.87%,P0.01),and the positive rate of p-AKT was significantly higher in colon carcinoma (87.5%) than that in normal control tissues (15.62%,P0.01),and expression level of PTEN and p-AKT were related to histological differentiation,distant invasion,lymph node metastasis and Duke's stage (P0.05). A negative correlation was observed between the expression of PTEN and p-AKT proteins. (r=-0.872,P0.01). Conclusion The over-expression of AKT accompanied by the loss of PTEN involves carcinogenesis and development of colon carcinoma.

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Available abstract

Objective To investigate the expression of PTEN in carcinogenesis and development of colon carcinoma and to reveal their correlation with the PI3K/AKT pathway. Methods The expressions of PTEN and p-AKT were detected by immunohistochemistry and western blotting in 32 specimens from patients with colon carcinoma. Results The positive rate of p-PTEN was significantly lower in colon carcinoma (31.25%) than that in normal control tissues (96.87%,P0.01),and the positive rate of p-AKT was significantly higher in colon carcinoma (87.5%) than that in normal control tissues (15.62%,P0.01),and expression level of PTEN and p-AKT were related to histological differentiation,distant invasion,lymph node metastasis and Duke's stage (P0.05). A negative correlation was observed between the expression of PTEN and p-AKT proteins. (r=-0.872,P0.01). Conclusion The over-expression of AKT accompanied by the loss of PTEN involves carcinogenesis and development of colon carcinoma.

Key concepts: PTEN, Immunohistochemistry, Protein kinase B, Carcinogenesis, PI3K/AKT/mTOR pathway, Cancer research, Carcinoma, Medicine

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