Evaluation on efficacy of atorvastatin in the prevention and treatment of 42 cases with acute ischemic stroke

Objective To observe the clinical efficacy and safety of atorvastatin in the prevention and treatment of acute ischemic stroke. Methods Atotal of 84 cases of acute ischemic stroke admitted during the same period were randomly divided into the observation group and the control group, and each group had 42 cases. The patients in the control group were treated with basic therapy and 100 mg oral enteric aspirin tablet each times, 1 times a day; The patients in the observation group were treated with basic therapy and oral enteric aspirin tablet, as well as 20 mg oral atorvastatin each times, 1 times a day, and a month was a course of treatment in the two groups. The efficacy and changes of blood lipid levels before and after the treatment in the two groups were observed, and the adverse reactions of patients during the treatment phase were recorded, including gastrointestinal reactions, unusual liver function, oral hemorrhage, cerebral hemorrhage, rash. Results The total effective rate of the control group was 69.0%(29/42), while that of the observation group was 88.1%(37/42), and the total effective rate of the observation group was obviously higher than that of the control group. The comparison of blood lipid levels in the two groups between before and after the treatment showed that compared with the control group, the TG, TC and LDL-C levels in the observation group improved more obviouly(P0.05), while the blood lipid levels in the control group improved less obviously; 2 cases(4.8%) were acute cerebral infarction among the 42 cases of the observation group, which was lower than that of the control group[5 cases(11.9%)]. Conclusion Atorvastatin has prominent curative effect, high security in the prevention and treatment of acute ischemic stroke, and can significantly improve the blood lipid levels, and has low incidence rate of adverse reactions, and it is worthy of clinical application.