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2002•Chinese Journal of Hospital PharmacyRequires access

HPLC determination of tinidazole contents in tinidazole gel

Wang Yan

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Abstract

OBJECTIVE To prepare a tinidazole gel and establish an HPLC method with metronidazole as internal standard to determine the content. METHODS The chromatographic column; Hypersil-C18 column. Mobile phase:methanol-water-36%acetic acid (30:70:0.5). Flow rate: 1.0 mL·min-1. Detection wavelength: 318 nm. Sensitivity: 0.08 AUFS. RESULTS The calibration curve was linear in the range of 41.84-125.52 mg·L-1 ( r = 0. 9997). Average recovery was 97. 92 % with RSD 1.02%.CONCLUSIONS The method is accurate, rapid, and suitable for the quality-control of the gel.

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What this paper is about

OBJECTIVE To prepare a tinidazole gel and establish an HPLC method with metronidazole as internal standard to determine the content. METHODS The chromatographic column; Hypersil-C18 column. Mobile phase:methanol-water-36%acetic acid (30:70:0.5). Flow rate: 1.0 mL·min-1. Detection wavelength: 318 nm. Sensitivity: 0.08 AUFS. RESULTS The calibration curve was linear in the range of 41.84-125.52 mg·L-1 ( r = 0. 9997). Average recovery was 97. 92 % with RSD 1.02%.CONCLUSIONS The method is accurate, rapid, and suitable for the quality-control of the gel.

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Available abstract

OBJECTIVE To prepare a tinidazole gel and establish an HPLC method with metronidazole as internal standard to determine the content. METHODS The chromatographic column; Hypersil-C18 column. Mobile phase:methanol-water-36%acetic acid (30:70:0.5). Flow rate: 1.0 mL·min-1. Detection wavelength: 318 nm. Sensitivity: 0.08 AUFS. RESULTS The calibration curve was linear in the range of 41.84-125.52 mg·L-1 ( r = 0. 9997). Average recovery was 97. 92 % with RSD 1.02%.CONCLUSIONS The method is accurate, rapid, and suitable for the quality-control of the gel.

Key concepts: Tinidazole, Chromatography, Calibration curve, High-performance liquid chromatography, Chemistry, Content determination, Acetic acid, Methanol

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