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2007•Journal of Bengbu Medical CollegeRequires access

Survivin gene in auxiliary diagnosis of gastric carcinoma

Yisheng Tao

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Abstract

Objective:To explore the value of the expression of survivin gene in auxiliary diagnosis of gastric cancer.Methods:The gastric carcinoma tissues and the neighboring noncancerous tissues of 49 cases with histologically verified gastric carcinoma were obtained.The survivin mRNA level was measued by RT-PCR and the protein expression of survivin was detected by immunohistochemical assay.Results:Survivin mRNA proved positive in 65.3%(32 cases)of the gastric cancerous tissues and 63.3%(31cases)of the protein respectively.In contrast,no expression of survivin was detected in the corresponding noncancerous tissues.The expression of survivin gene detected by RT-PCR was a bit higher than IHC,with no statistical significance(P0.05).Conclusions:The expression of survivin in gastric cancerous tissues is up-regulated.Detection of survivin gene by immunohistochemistry or RT-PCR would be a new method in diagnosis of gastric cancer.

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What this paper is about

Objective:To explore the value of the expression of survivin gene in auxiliary diagnosis of gastric cancer.Methods:The gastric carcinoma tissues and the neighboring noncancerous tissues of 49 cases with histologically verified gastric carcinoma were obtained.The survivin mRNA level was measued by RT-PCR and the protein expression of survivin was detected by immunohistochemical assay.Results:Survivin mRNA proved positive in 65.3%(32 cases)of the gastric cancerous tissues and 63.3%(31cases)of the protein respectively.In contrast,no expression of survivin was detected in the corresponding noncancerous tissues.The expression of survivin gene detected by RT-PCR was a bit higher than IHC,with no statistical significance(P0.05).Conclusions:The expression of survivin in gastric cancerous tissues is up-regulated.Detection of survivin gene by immunohistochemistry or RT-PCR would be a new method in diagnosis of gastric cancer.

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Available abstract

Objective:To explore the value of the expression of survivin gene in auxiliary diagnosis of gastric cancer.Methods:The gastric carcinoma tissues and the neighboring noncancerous tissues of 49 cases with histologically verified gastric carcinoma were obtained.The survivin mRNA level was measued by RT-PCR and the protein expression of survivin was detected by immunohistochemical assay.Results:Survivin mRNA proved positive in 65.3%(32 cases)of the gastric cancerous tissues and 63.3%(31cases)of the protein respectively.In contrast,no expression of survivin was detected in the corresponding noncancerous tissues.The expression of survivin gene detected by RT-PCR was a bit higher than IHC,with no statistical significance(P0.05).Conclusions:The expression of survivin in gastric cancerous tissues is up-regulated.Detection of survivin gene by immunohistochemistry or RT-PCR would be a new method in diagnosis of gastric cancer.

Key concepts: Survivin, Immunohistochemistry, Medicine, Cancer, Cancer research, Messenger RNA, Gene, Gene expression

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