Experiment Research about Resistant Effects of Penthorum chinese on Nonalcoholic Fatty Liver

Objective: To study the resistant effects of Penthorum chinese extract on nonalcoholic fatty liver and possible therapeutic mechanism. Method: The experimental rats were divided into 6 groups: the control group,the model group,fenofibrate group(33 mg·kg-1),P. chinense high-dose,middle-dose and low-dose group(16. 7,8. 4,4. 2 g·kg-1). Except the control group,nonalcoholic fatty liver model was induced by fatty emulsion intragastrically for 9 weeks,those groups were given relevant medicine intragastrically. At the end of 9 weeks,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),cholesterol(CHO),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) in blood were examined. Total choesterol(TC),TG,free fatty acid(NEAF),malondialdehyde(MDA),total superoxide dismutase(T-SOD),glutathione peroxidase(GSH-Px) in hepatic tissue were detected,and the hepatic tissue pathological changes were observed. Result: Compared with the control group,all the indexs showed significant difference(P 0. 05 or P 0. 01),the content of ALT,TBIL,TG,LDL-C in serum and TG,NEAF,MDA in hepatic tissue increased obviously,HDL-C decreased significantly,and the activity of GSH-Px decreased apparently. And pathological examination indicated steatosis appeared. Compared with model group,the content of ALT,TBIL,CHO,TG in the serum decreased in P. chinense groups(16. 7,8. 4,4. 2 g·kg-1),and HDL-C improved a little,TG and NEAF in the hepatic tissue decreased obviously,the activity of GSH-Px improved significantly(P 0. 05 or P 0. 01). The pathological images of hepatic tissue and classified graded method of steatosis improved. Conclusion: P. chinese can treat nonalcoholic fatty liver. Its therapeutic mechanism is partly related to regulating lipid metabolism and anti-oxidative damage.