Expression of activated antigens on peripheral blood T lymphocytes in patients with condyloma acuminatum

Objective:To investigate the expression of special marker for activation on peripheral blood T lymphocytes in patients with condyloma acuminatum(CA) and its significance.Methods:Immunofluorescent three color flow cytometry was used to study the expression of CD69 and HLA DR on T lymphocytes in 30 patients with CA and 31 normal controls. Results:Expression of CD69 on CD3 + T cells were significantly higher in patients (6 63%±3 13%) than that in controls (5 12%±1 64%, P 0 05),meanwhile the expression of CD69 on CD8+ T cell was a significant difference between patients (4 61%±3 09%) and that in controls(2 67%±1 31%, P 0 01) . The percentages of CD3 + T cells expressing HLA DR were significantly higher in patients(21 65%±8 84%) than that in controls (13 56%±5 15%, P 0 001). Conclusion:The findings support that activation of peripheral blood T lymphocytes in CA is primarily in the CD8+ subset, it may play an important role in the immune response to antiviral infection.