Detection of Co-stimulatory Molecule in Peripheral Blood Mononuclear Cells of Patients with Condyloma Acuminatum

Objective To investigate the expression of immune co-stimulatory molecules CD28/CD152-CD80/CD86, CD40-CD40L in peripheral blood mononuclear cells (PBMC)of patients with condyloma acuminatum. Methods Flow cytometry (FCM) technique was applied to analyze the expression level of CD28, CD152, CD40L on CD4+, CD8+T cells and CD80, CD86, CD40 on CD19+B cells. Results The CD28, CD40L expressed on CD4+, CD8+T cells and the CD80, CD86, CD40 expressed on CD19+B cells in CA patients (37.1%,11.66%,2.57%,1.25%, and 39.69%,12.76%,3.93%,1.96%;0.65%,3.05%,10.24% and 1.04%, 3.45%, 12.21%, 39.20%,12.51% and 2.64%,10.96%) were all significant lower than those in healthy controls(42.36%, 13.85%, 5.08%, 2.58%, 1.59%, 3.83%, 14.25%; 1.71%, 9.62%) (P0.01), and CD152 on CD4+, CD8+T cells was significant higher than that in the normal control group (P0.01). Conclusion The changes of peripheral blood lymphocyte level and expression of co-stimulatory molecules may be related to immunologic dysfunction and relapse in patients with condyloma acuminatum.