CLINICAL STUDY OF THE EFFICIENCY AND SAFETY OF PATIENT CONTROLLED ANALGESIA WITH LORNOXICAM IN SCHOOL CHILDREN

Objective:To assess the analgesic effect and safety of patient controlled analgesia(PCA) with lornoxicam in patient compared with tramadol. Methods: 60 patients undergoing surgical treatments of gluteus muscle contracture with epidural analgesia and ketamine anesthesia were randomly divided into two groups: group L received PCA with lornoxicam and group T received PCA with tramadol. At the end of operation, 0.15mg/kg lornoxicam was injected as starting dose, 0.3mg/kg lornoxicam was diluted to 100ml with normal saline into PCA pump in group L, and 1mg/kg tramadol was injected as starting bolus dose, 10mg/kg tramadol was diluted to 100ml with normal saline into PCA pump in Group T. The subjects received PCA at the following dosages: bolus dose = 2ml; background infusion = 5ml/h. Lockout was for 15 minutes. After PCA had been started, pain scores,global impression score and side effects were assessed at 1h, 4h, 8h, 12h, 20h. Results: There was no difference in pain scores and global impression scores for PCA between the two groups( P 0.05). Lornoxicam caused fewer adverse effects than tramadol( P 0.01). There was no difference in changes of hepatic, renal functions and coagulation before and after PCA( P 0.05).Conclusions: These results indicate that using Lornoxicam via PCA is an effective and safe method to control postoperative pain as well as tramadol in children.