The Comparison of Patient-Controlled Analgesia with Lornoxicam in Combination with a Small Dose of Fentanyl Versus Tramadol

Objective:To evaluate the effects and the side effects of lornoxicam in combination with a small dose of fentanyl versus tramadol for postoperative patient-controlled intravenous analgesia(PCIA).Methods:80 ASA Ⅰ-Ⅱ patients scheduled for radical mastectomy were randomly divided into the study group and the control group.The patients in the study group were administrated with 48mg lornoxicam and 0.3mg fentanyl which were diluted with 0.9% NS to 100ml,while the patients in the control group were administrated with 1000mg tramadol and 5mg droperidol which were diluted with 0.9% NS to 100ml.All of the patients received PCIA soon after extubation(background infusion 2ml/h,bolus dose 4ml,PCA 0.5ml/time,lock-pump interval 15min).The times of PCA,pain score(VAS)and the incidence of side effects were recorded at 4,8,12,24 and 48 hours after operation.Results:There was no significant difference in VAS between the two groups(P0.05),but the times of PCA and the incidence of nausea,vomiting,vertigo and lethargy in the study group were obviously less than those in the control group(P0.05).Conclusion:Lornoxicam in combination with a small dose of fentanyl produced favourable analgetic effects and less incidence of the side effects,which could be a choice for the multiple pattern of analgetics.