Clinical Efficacy of Nimodipine in the Treatment of Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage

OBJECTIVE:To explore the clinical efficacy of nimodipine in the treatment of cerebral vasospasm (CVS) after aneurysmal subarachnoid hemorrhage (aSAH) in order to provide reference for clinical application of nimodipine. METHODS:The clinical informations of 166 patients with aSAH were analyzed retrospectively. Patients were randomly divided into nimodipine group and control group. Both groups were given strict bed rest and other therapy including hemostasis and dewatering. Nimodipine group were additionally given continuous perfusion of nimodipine. The incidence of CVS rate and mortality were evaluated. RESULTS: All cases were applied with intravascular intervention treatment. The incidence of CVS rate and mortality of nimodipine group were lower than control group 2 weeks after operation, there were statistical significance (P0.05). CONCLUSION: Nimodipine can significantly reduce the incidence of CVS after aSAH, decrease the risk of rehaemorrhage. It is necessary for aSAH patient to administer nimodipine at early stage.