Clinical Significances of α_1-microglobulin and β_2-microglbulin in Early Renal Injury of the Patients Suffering from Essential Hypertension

Objective: To explore clinical significance of detecting α1-microglobulin(α1-MG) and β2-mi-croglbulin(β2-MG) in early renal injury of the patients with essential hypertension(EH). Methods: Fifty-five patients were divided into group A(26 cases) and group B(29 cases) according to Ccr85 mL/min and 85 mL/minCcr110 mL/min, another 60 cases were chosen as normal control group, the contents of α1-MG and β2-MG in the blood and urine were detected with immunoturbidimetry assay(ITM). Results: The contents of α1-MG and β2-MG in the blood and urine in group A were improved significantly compared with the control group(P0.01); the comparison had no significant difference in the contents of β2-MG in the blood and urine when group B was compared with the control group(P0.05), it had significant difference in the contents of α1-MG in the blood and urine when group B was compared with the control group(P0.05); the difference showed statistical meaning when group B was compared with group A in the contents of α1-MG and β2-MG in the blood and urine(P0.05). Conclusion: Combination detection of α1-MG and β2-MG in the blood and urine could reflect the degree of early renal injury of EH patients,and the detection shows important clinical value in early diagnosis.