Clinical analysis of 41 cases with apiastic anemia

Objective To analyze the clinical characteristics and diagnosis and treat- ment outcome in 41 cases with aplastic anemia (AA).Method We registered patients newly diagnosed AA between 1993 and 2003 using questionnaires. Retospective analysis was used. Result Of the 41 cases, Treatment effective rate was 80% of chronic AA, 42.9% of severe AA. In chronic AA, the rate was 83.3% in treatment with cyclosporine A combined androgen and 76.9% with androgen alone. In severe AA, the rate was 50% with cyclosporine A combined androgen versus 25% with androgen alone. The main cause of death was brain bleeding (60%).Conclusion Androgen was a main drug for chronic AA. Androgen combined with cyclosporine A could increase the effective rate.But for severe AA, androgen was not an effective drug. Cyclosporine A or ATG was recommended for severe AA. Cyclosporine A combined with ATG and high does methylprednisolone and hematopoietic cytokine would improve the trearment outcome.