2007•Journal of Guangdong Medical CollegeRequires access
Expression of survivin,PTEN and PCNA protein in endometrial carcinoma and its clinical significance
LI Ying-yong
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Abstract
Objective To investigate the expression of survivin,PTEN and PCNA protein in endometrial carcinoma and its clinical significance.Methods Immunohistochemical SP method was performed to detect the expression of survivin,PTEN and PCNA protein in 48 cases of endometrial carcinoma,19 cases of endometrial atypical hyperplasia and 23 cases of normal endometrium.The expression of survivin,PTEN and PCNA protein was detected in different clinical stage,histological grade,myometrial invasion of endometrial carcinoma.Results The expression of survivin,PCNA and PTEN protein in normal endometrium,endometrial atypical hyperplasia and endometrial carcinoma were significantly different(endometrial atypical hyperplasia vs normal endometrium with P0.05,and endometrial carcinoma vs normal endometrium with P0.01,while endometrial carcinoma vs endometrial atypical hyperplasia with P0.05).In endometrial carcinoma,the expression of survivin in clinical stage Ⅱgroup and Ⅲ～Ⅳgroup was different from in the stageⅠgroup(P0.05);the expression of PTEN and PCNA in clinical stage Ⅲ～Ⅳgroup was different from in stageⅠgroup(P0.05).The expression of survivin,PTEN and PCNA in histological G2,G3 grade groups of endometrial carcinoma was different from in G1 grade group(P0.05 or 0.01).Conclusion Detection of the expression of surviving,PTEN and PCNA could supply some clues for the malignant degree of endometrial carcinoma and the prognosis of patients.