Increased Serum High Sensitivity C-reactive Protein Level is Associated with Diffuse Coronary Artery Lesions in Patients with Type 2 Diabetes

Objective The aim of this study was to determine the prognostic value of high sensitivity C-reactive protein(hsCRP)for diffuse coronary artery lesions in patients with type 2 diabetes.Methods A total of 296 patients with coronary artery disease(CAD)confirmed by angiography were divided into 5 groups based upon coronary angiographic findings and with or without diabetes:92 patients had focal coronary artery lesions without diabetic(group I),78 patients had diffuse coronary artery lesions without diabetes(group II),30 patients had diabetes but not CAD(group III),32 diabetic patients with focal coronary artery lesions(group IV);and 64 diabetic patients with diffuse coronary artery lesions(group V),Serum levels of hsCRP,TNF-α and IL-6 were measured in all subjects.Results Serum hsCRP level was significantly higher(p0.01)in group V than that in other four groups(14.65±8.74 vs.7.78±5.91,9.16±8.13,7.47±4.62,10.58±7.43 mg/L),and Serum hsCRP level in group IV was significantly(p0.05)higher than that in group I and group III.IL-6 level was significantly(p0.05)higher that in group V than in group II and group III.The level of TNF-α in group IV was significantly(p0.05)higher than that in group II and group III.The levels of IL-6 in group IV and TNF-α in group V were higher than those in group I,II and III,but there was no significantly difference.There was no significantly difference for the levels of hsCRP,IL-6 and TNF-α between group I and group II.hsCRP was positive correlation with diffuse coronary artery lesions and diabetic.Conclusions Increased serum hsCRP level in patients with type 2 diabete is an important risk factor for diabetic atherosclerosis complication,futher more it is associated with the extent and severity of coronary artery lesions in type 2 diabetes.