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Expressions of NOS2 and NOS3 in human non-small cell lung cancer and the relationship with tumor angiogenesis and lymph node metastasis

Wang Jinghua

Open publisher page 1 citations

Abstract

Objective: To investigate the expression and distribution of NOS2 and NOS3 in human non-small cell lung cancer (NSCLC),and to evaluate the relationship between their expression and tumor angiogenesis and lymph node metastasis. Methods: the expression of NOS2, NOS3 and IMVD in 95 patients with NSCLC were examined using immunohistochemical methods (S-P), and the relationship between them and many clinicopathological parameters was analyzed. Results: The positive expression of NOS3 was associated with histological subtype, IMVD and lymph node metastases of NSCLC(P0.05), while NOS2 was associated with IMVD(P0.05). Conclusion: NOS2 and NOS3 may be synergetic in tumor angiogenesis and lymph metastasis of human NSCLC.The detection of NOS2 and NOS3 may be valuable for the prediction of human NSCLC metastasis and prognosis.

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What this paper is about

Objective: To investigate the expression and distribution of NOS2 and NOS3 in human non-small cell lung cancer (NSCLC),and to evaluate the relationship between their expression and tumor angiogenesis and lymph node metastasis. Methods: the expression of NOS2, NOS3 and IMVD in 95 patients with NSCLC were examined using immunohistochemical methods (S-P), and the relationship between them and many clinicopathological parameters was analyzed. Results: The positive expression of NOS3 was associated with histological subtype, IMVD and lymph node metastases of NSCLC(P0.05), while NOS2 was associated with IMVD(P0.05). Conclusion: NOS2 and NOS3 may be synergetic in tumor angiogenesis and lymph metastasis of human NSCLC.The detection of NOS2 and NOS3 may be valuable for the prediction of human NSCLC metastasis and prognosis.

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Available abstract

Objective: To investigate the expression and distribution of NOS2 and NOS3 in human non-small cell lung cancer (NSCLC),and to evaluate the relationship between their expression and tumor angiogenesis and lymph node metastasis. Methods: the expression of NOS2, NOS3 and IMVD in 95 patients with NSCLC were examined using immunohistochemical methods (S-P), and the relationship between them and many clinicopathological parameters was analyzed. Results: The positive expression of NOS3 was associated with histological subtype, IMVD and lymph node metastases of NSCLC(P0.05), while NOS2 was associated with IMVD(P0.05). Conclusion: NOS2 and NOS3 may be synergetic in tumor angiogenesis and lymph metastasis of human NSCLC.The detection of NOS2 and NOS3 may be valuable for the prediction of human NSCLC metastasis and prognosis.

Key concepts: Angiogenesis, Immunohistochemistry, Lung cancer, Metastasis, Medicine, Lymph node metastasis, Lymph, Pathology

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