Expressions of b-FGF in human non-small cell lung cancer and its clinicopathological significance

Objectives:To investigate the expression and distribution of b FGF in human non small cell lung cancer (NSCLC),and to evaluate the relationship between the expression of b FGF and the biological behavior of NSCLC, especially tumor angiogenesis and lymph node metastasis. Methods:The expression of b FGF and IMVD in 95 patients with NSCLC was examined using immunohistochemical methods (SP), and the relationship between the expression and many clinicopathological parameters were analyzed. Results: The positive rates of b FGF in carcinoma tissue (NSCLC) were much higher than those in the normal lung tissues nearby ( P 0.05). The positive expression of b FGF was associated with IMVD , lymph node metastases , and TNM stage of NSCLC( P 0.05),and the expression was not related to the histological subtype and pathological grade ( P 0.05). Conclusions: b FGF may play an important role in tumor angiogenesis and lymphatic metastasis of human NSCLC , and detection of b FGF may be a good metastasis and prognostic predictors for human NSCLC.