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2006•Tianjin Yike Daxue xuebaoRequires access

Correlation between matrix metalloproteinase-9 and the invasion and metastasis of colorectal cancer

Pengzhi Wang

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Abstract

Objective: To study the transcription level and expression level of MMP-9 in colorectal cancer and explore its function and the mechanism during the invasion and metastasis.Methods: The quantitative-RT-PCR and immunohistochemical method were employed to determine the transcription level and expression level of MMP-9 in 41 cases of colorectal cancer,including the cancer tissue and the distal cut margin.Results: Both the transcription level and expression level of MMP-9 in the cancer tissue were significantly higher than in the distal normal tissue.And the results were correlated with the invasion depth,lymph node metastasis and Dukes stage.Conclusion: MMP-9 plays an important role in the invasion and metastasis of colorectal cancer and is helpful for the judgment of prognosis.

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What this paper is about

Objective: To study the transcription level and expression level of MMP-9 in colorectal cancer and explore its function and the mechanism during the invasion and metastasis.Methods: The quantitative-RT-PCR and immunohistochemical method were employed to determine the transcription level and expression level of MMP-9 in 41 cases of colorectal cancer,including the cancer tissue and the distal cut margin.Results: Both the transcription level and expression level of MMP-9 in the cancer tissue were significantly higher than in the distal normal tissue.And the results were correlated with the invasion depth,lymph node metastasis and Dukes stage.Conclusion: MMP-9 plays an important role in the invasion and metastasis of colorectal cancer and is helpful for the judgment of prognosis.

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Available abstract

Objective: To study the transcription level and expression level of MMP-9 in colorectal cancer and explore its function and the mechanism during the invasion and metastasis.Methods: The quantitative-RT-PCR and immunohistochemical method were employed to determine the transcription level and expression level of MMP-9 in 41 cases of colorectal cancer,including the cancer tissue and the distal cut margin.Results: Both the transcription level and expression level of MMP-9 in the cancer tissue were significantly higher than in the distal normal tissue.And the results were correlated with the invasion depth,lymph node metastasis and Dukes stage.Conclusion: MMP-9 plays an important role in the invasion and metastasis of colorectal cancer and is helpful for the judgment of prognosis.

Key concepts: Colorectal cancer, Metastasis, Matrix metalloproteinase, Medicine, Immunohistochemistry, Lymph node metastasis, Oncology, Matrix metalloproteinase 9

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