ScholarLens Back to search
2006•Journal of Nantong UniversityRequires access

Relationship between expression of COX-2 and MMP-7 and metastasis in colorectal cancer

Weidong Hu

Open publisher page 0 citations

Abstract

Objective:To investigate the expression of COX-2 and MMP-7 and their influence on invasion and metastasis in colorectal cancer.Methods:Immunohistochemical methods were used to detect the expression of COX-2 and MMP-7 in 62 case of colorectal carcinomas.Results:The positive rate of the expressions of COX-2 and MMP-7 was significantly higher in colorectal cancer tissues than in normal tissues(P0.05).The overexpressions of COX-2 and MMP-7 were correlated to lymph node metastasis,Dukes grade of carcinoma and depth of invasion(P0.05).A significant correlation was found between COX-2 and MMP-7.Conclusion:The overexpressions of COX-2 and MMP-7 are strongly related to the invasion and metastasis of colorectal carcinoma and they may be a valuable indictor for assessing prognosis and for selecting suitable therapy for patients.

About this research paper

What this paper is about

Objective:To investigate the expression of COX-2 and MMP-7 and their influence on invasion and metastasis in colorectal cancer.Methods:Immunohistochemical methods were used to detect the expression of COX-2 and MMP-7 in 62 case of colorectal carcinomas.Results:The positive rate of the expressions of COX-2 and MMP-7 was significantly higher in colorectal cancer tissues than in normal tissues(P0.05).The overexpressions of COX-2 and MMP-7 were correlated to lymph node metastasis,Dukes grade of carcinoma and depth of invasion(P0.05).A significant correlation was found between COX-2 and MMP-7.Conclusion:The overexpressions of COX-2 and MMP-7 are strongly related to the invasion and metastasis of colorectal carcinoma and they may be a valuable indictor for assessing prognosis and for selecting suitable therapy for patients.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To investigate the expression of COX-2 and MMP-7 and their influence on invasion and metastasis in colorectal cancer.Methods:Immunohistochemical methods were used to detect the expression of COX-2 and MMP-7 in 62 case of colorectal carcinomas.Results:The positive rate of the expressions of COX-2 and MMP-7 was significantly higher in colorectal cancer tissues than in normal tissues(P0.05).The overexpressions of COX-2 and MMP-7 were correlated to lymph node metastasis,Dukes grade of carcinoma and depth of invasion(P0.05).A significant correlation was found between COX-2 and MMP-7.Conclusion:The overexpressions of COX-2 and MMP-7 are strongly related to the invasion and metastasis of colorectal carcinoma and they may be a valuable indictor for assessing prognosis and for selecting suitable therapy for patients.

Key concepts: Colorectal cancer, Medicine, Metastasis, Matrix metalloproteinase, Immunohistochemistry, Lymph node metastasis, Proportional hazards model, Oncology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Relationship between expression of COX-2 and MMP-7 and metastasis in colorectal cancer — Research Paper | ScholarLens