Associations between Hind III gene polymorphism of lipoprotein lipase and atherosclerotic cerebral infarction

Objective To study the associations between Hind Ⅲ gene polymorphism of LPL and atherosclerotic cerebral infarction and to investigate the effect of Hind Ⅲ gene polymorphism on plasma lipids,carotid intima-media thickness (IMT) and carotid artery plaque (CAP) in patients with atherosclerotic cerebral infarction.Methods PCR-RFLP technique was used to detect Hind Ⅲ gene polymorphism of lipoprotein lipase gene in 166 patients with atherosclerotic cerebral infarction (CI group) and 72 healthy subjects (control group). Carotid IMT and CAP were measured with carotid color ultrasonographic Doppler for the patients and the controls. Results The frequencies of the H+H+ genotypes and H+ allele gene in CI group were significantly higher than those in control group (OR=2.267,P=0.004 and OR=1.903, P=0.004). There was no statistical difference of plasma lipids and IMT between CI and control groups. Conclusions The polymorphism of LPL Hind Ⅲ gene is associated with CI. H+H+ genotype may be a risk factor of CI.