Studies on Inclusion Mechanism of 14-Deoxy-11,12-Didehydroandrographolide/β-Cyclodextrin

Studies on inclusion mechanism of 14-deoxy-11,12-didehydroandro-grapholide and β-cyclodextrin in the inclusion ratio,the molecular interaction between host and guest,inclusion part and stability of inclusion compound.The formation of inclusion compound was confirmed by DTA;the equilibrium constants of inclusion compound was determined by UV and the calculated thermodynamic constants through Ka of various temperature;inclusion parts were confirmed by the 1H-NMR and IR.The results indicated that inclusion host-guest ratio is 1∶1,van der Waals forces play a major role in the process,inclusion site is five yuan lactone ring and decalin ring,the inclusion compound is more stable under normal temperature.