Inclusion of 14-deoxyandrographolide/β-cyclodextrin

Objective To study the inclusion of 14-deoxyandrographolide and β-cyclodextrin.Methods The inclusion compound of 14-deoxyandrographolide-β-cyclodextrin was prepared by saturated solution method assisted with microwave.Equilibrium constant of inclusion complexes and molar ratio of 14-deoxyandrographolide and β-CD were determined by UV,and the inclusion compound was confirmed by IR and 1H-NMR.Results The 14-deoxyandrographolide and β-cyclodextrin formed inclusion compound.The equilibrium constant of inclusion complexes was 1 315.789 mol·L-1,and the molar ratio was 1∶1.Conclusion The 14-deoxyandrographolide could be included by β-cyclodextrin and the inclusion effect is good.