Significance of determination of high sensitive C-reactive protein in diagnosis of acute coronary atery syndrome

Objective To investigate the diagnostic value of determining high sensitive C reactive protein (hs-CRP) in acute coronary artery syndrome (ACS) and to explore its clinical significance.Methods 94 ACS patients confirmed by coronary angiography were randomly recruited, including 32 cases of acute myocardial infarction (AMI),41 cases of unstable angina pectoris(UAP) and 31 cases of stable angina pectoris(SAP).Another 35 healthy persons were recruited as control group.Their levels of serum hs-CRP were determind by transmission immunity nephelometery, and serum cardiac specific troponin I(TnI),creatine kinase isoenzyme Mb(CK-Mb),and myohemoglobin(Mb)were analysed respectively.Results Similar to cTnI,CK-Mb and Mb, the plasma hs-CRP levels increased sequentially in the normal control group,the stable angina pectoris group,the unstable angina ectoris group and acute myocardial infaction. hs-CRP concentration of ACS patients was significantly higher than that of the control group(P0.01or P0.05).The levels of hs-CRP of AMI group were significantly higher than those in UAP group(P0.01),the levels of hs-CRP of UAP group were significantly higher than those in SAP group(P0.01).Meanwhile,positive rate of hs-CRP, cTnI,CK-Mb and Mb in the diagnosis of AMI was 91%,97%,81% and 67% respectively. The hs-CRP level of one vessel lesion group, 2 vessels group and 3 vessels lession group were increased sequentially, and were significantly higher than that in normal control group(P0.01).In predicting cardiac events during observation,the sensitivity and sepecificity of hs-CRP were 75.0%,78.9% respectively and that of cTnI were 91.3%,89.2%.Conclusion The level of serium hs-CRP in ACS increases significantly. hs-CRP is of great value to the diagnosis,treatment and prognosis of ACS.