A Contrast study between Mirtazapine and Venlafaxine in the treatment of Co morbidity of Depression with Anxiety Disorder

Objective:To compare with the efficacy and safety of Mirtazapine and Venlafaxine in the treatment of depression and anxiety disorder. Methods: At the same time, in line with China in line with the classification of mental disorders third edition of the diagnostic criteria and diagnostic criteria for depression (CCMD-3) , 68 patients were randomly given Mirtazapine and Venlafaxine in the treatment were observed for 6 weeks. Application of Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA) response and vice-scale (TESS) to evaluate and compare the efficacy and safety. Results: Mirtazapine group 4 weeks and 6 weeks of the HAMD, HAMA total score and the reduction rate with the Venlafaxine group had no significant difference (P0.05), Mirtazapine group efficacy and Venlafaxine Group similar (P0.05). However, Mirtazapine group in improving sleep and physical symptoms than Venlafaxine group and markedly faster (P0.05). Mirtazapine group of fewer adverse reactions, but the two groups no significant difference (P0.05). Conclusions: Mirtazapine treatment of depression and anxiety disorder of the efficacy and adverse reactions with Venlafaxine rather, to improve sleep and somatic symptoms better and earlier onset.