Efficacy analysis of Sertraline combined with small-dose Mirtazapine in treatment of depression with anxiety symptoms

Objective: To investigate the efficacy and side effects of Sertraline combined with small-dose Mirtazapine in treatment of depression with anxiety symptoms. Methods: 79 patients with depression with anxiety symptoms were recruited and numbered by the sequence of visiting and diagnosing. The odd numbers were assigned to control group( sertraline only),and the even numbers were study group( sertraline combined with mirtazapine),and the treatment lasted for 6 weeks. The efficacy was evaluated with Hamilton depression scale( HAMD) and Hamilton anxiety scale( HAMA),and the side effects were evaluated with treatment emergent symptoms scale( TESS). Results: The total scores of HAMD and HAMA in study group were significantly lower than those in control group after 6 weeks' treatment( P 0. 05 or P 0. 01). No significant differences were found in side effects between the two groups( P 0. 05). Conclusions: The efficacy of sertraline combined with mirtazapine is better than that of sertraline only in the treatment of depression with anxiety symptoms,and mirtazapine has an auxiliary action in the treatment.