Protective Effects of Losartan on Endothelial and Kidney Functions in Patients with Essential Hypertension

OBJECTIVE:To investigate the protective effect of losartan on endothelial and kidney functions in patients with essential hypertension.METHODS:40 patients with mild or moderate primary hypertension(observation group) were given losartan 50 mg·d-1 orally to 100 mg·d-1 if the blood pressure was not controlled well for 16 weeks.The changes of blood pressure were observed before and after therapy.The changes of FMD,U-MALB level,β2-MG content and ADR were determined.30 healthy people were set as control group.RESULTS:The level of FMD in observation group was significantly lower than in control group,but the levels of U-MALB and β2-MG were opposite(both P0.01).16 weeks after treatment,the systolic and diastolic pressure of observation group were controlled well,and the FMD increased significantly than pre-therapy,but the levels of U-MALB and β2-MG were opposite(all P0.01),and increased significantly than control group(P0.05).No ADR was found during treatment.CONCLUSIONS:There are dysfunction of endothelial and kidney in patient with essential hypertension.Losartan can well decrease the blood pressure,improve the endothelial and kidney function.